Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent
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چکیده
منابع مشابه
Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent
To develop novel anti-ischemic stroke agents with better therapeutic efficacy and bioavailability, we designed and synthesized a series of 3-alkyl-2,3-dihydro-1H-isoindol-1-ones compounds (3a-i) derivatives, one of which (3d) exhibited the strongest inhibitory activity for the adenosine diphosphate-induced and arachidonic acid-induced platelet aggregation. This activity is superior to that of 3...
متن کامل2-Benzyl-3-hydroxy-3-methyl-2,3-dihydro-1H-isoindol-1-one
In the title compound, C(16)H(15)NO(2), the isoindoline ring system is approximately planar (mean deviation = 0.0186 Å) and makes a dihedral angle of 61.91 (4)° with the phenyl ring. In the crystal, mol-ecules form inversion dimers via pairs of O-H⋯O hydrogen bonds.
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The asymmetric unit of the title compound, C(27)H(16)F(2)N(2)O(4), consists of two crystallographically independent mol-ecules (A and B). In mol-ecule B, the isoindoline-1,3-dione ring system is disordered over two set of sites with a site-occupancy ratio of 0.658 (12):0.342 (12). In mol-ecule A, the fluoro-substituted benzene rings make dihedral angles of 18.36 (8) and 46.37 (8)° with the cent...
متن کامل1-Butyl-4-hydroxy-3-methylquinoline-2(1H)-one
In the crystal of the title compound, C(14)H(17)NO(2), mol-ecules are arranged into chains along the b axis linked via O-H⋯O hydrogen bonds. While the benzene ring is essentially planar, with a maximum deviation from the best plane of 0.003 (1) Å, the pyridine ring is slightly V-shaped: the distance of the carbonyl C atom from the benzene best plane is 0.120 (1) Å. The hy-droxy group is incline...
متن کامل{[(1Z)-3-Chloro-1H-isoindol-1-ylidene]methyl}dimethylamine
The asymmetric unit of the title compound, C11H11ClN2, contains two almost-planar independent mol-ecules: the isoindole and dimethyl-amino-methyl-ene mean planes in the two mol-ecules form dihedral angles of 5.45 (8) and 1.34 (8)°. The crystal packing exhibits no short inter-molecular contacts, except for a relatively short Cl⋯Cl distance of 3.4907 (7) Å.
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ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2015
ISSN: 1177-8881
DOI: 10.2147/dddt.s84731